The aim of this course is to introduce students to the main topics of economic methodology, linking foundational issues with practical problems that economists face in the confrontation of models with data. The course focuses on the role of models in economics, issues about measurement and confirmation, forms of explanations, interpretations of probability, epistemological issues in statistical and causal inference, rational choice theory, and the methodology of experimental economics. The last part of the course will be devoted to students’ presentations of key papers in economic methodology.